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darifenacin decreases effects of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Watch. Stops conversion of codeine to its Energetic metabolite morphine.Composition of Cough, The Energetic compound is codeine phosphate hemihydrate. Every ml of oral Remedy is made up of 2 mg of codeine phosphate hemihydrate.chloroquine will boost